The University of North Carolina

Oliver Smithies’ gene-targeting technique, first tried in 1985 at Wisconsin-Madison but developed to its potential here at UNC

Michael Knowles, John Gatzy, and Richard Boucher’s discovery that epethelial ion transport is a cause of cystic fibrosis (1981)

Clyde A. Hutchison’s method for creating mutations in DNA (1977)

Glen H. Elder Jr.’s seminal work, _Children of the Great Depression: Social Change in Life Experience_ (1974)

the Hulka clip, invented by Jaroslav Hulka and patented in 1975

Joseph DeSimone’s work in green chemistry, especially the use of supercritical CO2  in cleaning and manufacturing (1990s to present)

Fred Brooks’ pioneering work in virtual environments (computer science)